actually, spyware can be a b!7<|-| to get rid of. i dont have much, but i still need to get rid of some.
if spyware is hogging your computer that badly, then you probably should reformat or start weed whacking.
some tools for weed whacking
run>msconfig-startup options get rid of anything you dont know or appears in C:\Program Files\... it's probably not yours. a lot of the stuff is in a harder-to-read format for those not used to coder naming conventions, so try to be sure you're not getting rid of anything too special.
McAfee Suite, AFAIK probably the best anti-hacker program list around. the firewall has never failed me (and trust me, it's been tried) it has excellent anti-virus capablities and they have all the data on anything new, with updates within the week to counter it
Spybot Search and Destroy - i had mine in German at first, then managed to switch it back to English

excellent program for aiding other anti-virus ones, this lists the ones it finds. i never use it much since i dont have a big problem with spyware or anything liek that.
but if you're really loaded down with $|-|!7 then the best option is to make a list of everything you need, i mean
need, such as configs and favorite saves, maybe your favorites list. then do a reformat and replace your previous things. programs (as long as you have the disks) aren't hard to replace. but this is kinda drastic, if you're not completely clogged don't do it.